|
KMID : 0381219870190040347
|
|
Journal of RIMSK
1987 Volume.19 No. 4 p.347 ~ p.358
|
|
|
STI Changes of Midazolam and Thiopental Sodium
|
|
|
|
|
Abstract
|
|
|
To compare the cardiovascular effects of thiopental with those of midazolam, we selected 20 patients in ASA class I or II for thiopental group, and 20 for midazolam group. Without any pre medication thiopental 5 mg/kg in thiopental group, midazolam 0.25 mg/kg in midazolam group was injected intravenously.
And then we measured sBP (systolic BP), dBP(diastolic BP), MAP (mean arterial pressure), RPP (rate-pressure product) and TTI (tension time index) by noninvasive method, and STI which was measured by analysis of the integral data (QS2, LVET, PEP, PEP/LVET, 1/PEP2, S2Q and S2Q/QS2) from the electrocardiogram, phonocardiogram and carotid sphygmogram, in pre-injection state (control), and every two minutes for 15 minutes after injection in each group. All these STI values were given by AVL 970 Myocard, Check (automatic computed STI instrument), and corrected by Weissler´s regression equation. The results were as follows:
1) Compared with control value, sBP, dBP, MAP and TTI were significantly decreased in both groups. (p < 0.05)
2) HR was transiently increased at 1 minute after drug injection, but gradually decreased in both groups.
3) RPP was significantly decreased from 9 or 11 minutes after drug injection in both groups. (p< 0.05)
4) There were no significant changes in QS2C and LVETC, but PEPC and PEP/LVET were significantly increased in both groups. (p<0.05)
According to above results the cardiovascular effects of midazolam seems to be similar to those of thiopental, therefore midazolam can be used as the inducing agent of anesthesia instead of thiopental.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|